Dr. Althea 345 vs 147: cuál crema barrera elegir según tu piel

Barrier cream Dr. Althea 345 vs 147 for your skin

Your skin itches, feels tight, flakes, and no moisturiser seems to calm it. You have been using retinol or acids for weeks and your face feels like a desert. Or you have simply noticed that your skin now reacts to everything it used to tolerate. The problem is not hydration — it is the barrier. And the solution has a name: barrier cream.

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The skin barrier: what it is and why when it fails, everything fails

The skin barrier is the outermost layer of your skin — a wall of ceramides, fatty acids and cholesterol that keeps hydration in and keeps aggressors out (pollution, bacteria, irritants). When this barrier is damaged — by retinol, acids, cold weather, sun, stress or harsh cleansers — the skin loses water, becomes inflamed and irritated, and the active ingredients you apply sting instead of helping.

A barrier cream is not “just another moisturiser”. A barrier cream is a product specifically designed to rebuild that lipid wall with its natural components: ceramides (bricks), fatty acids (cement) and cholesterol (sealant). Dr. Althea 345 Relief Cream takes this a step further by adding centella asiatica (cica), which soothes inflammation while the ceramides help to rebuild.

In my practice it is the most dispensed K‑beauty barrier cream in our pharmacy, because it performs consistently well on compromised skin barriers.

  • The skin barrier is the outer layer of skin made of lipids such as ceramides, fatty acids and cholesterol that limit water loss.
  • A damaged skin barrier leads to increased irritation, inflammation and stinging from topical active ingredients.
  • A barrier cream is formulated to replenish structural lipids like ceramides rather than only providing surface hydration.

Ceramides and centella: why this combination supports damaged skin


The key point is that it does not just hydrate (like any standard face cream) but provides the structural lipids that the barrier needs to rebuild itself. The difference between hydrating and repairing is the difference between throwing water at a broken wall and actually rebuilding the wall.

  • Ceramides are essential lipids in the stratum corneum that help maintain an effective skin barrier function.
  • Centella asiatica extracts are widely used in cica creams for their soothing properties on irritated or sensitised skin.
  • Combining ceramides with centella targets both structural repair of the barrier and symptomatic relief of redness or discomfort.

When do you need a barrier cream?

🔴 If your skin is irritated by retinol, acids or peels
Yes. This is the main indication I see. Applying Dr. Althea 345 Relief Cream as the last step at night seals in your actives and calms irritation. Many dermatologists recommend it as part of a “retinol sandwich”: barrier cream → retinol → barrier cream.
❄️ If your skin reacts to cold weather, central heating or seasonal changes
Yes. Changes in temperature and humidity can damage the barrier. A barrier cream works as a protective shield during harsher months.
😷 If masks irritate your perioral area
Yes. Friction and trapped humidity under a mask damage the barrier on the chin and cheeks. Applying a barrier cream before putting on your mask reduces irritation.
🧴 If you use strong active treatments and want to maximise results
Yes. Sealing actives under a barrier cream increases their contact time with the skin and reduces loss through evaporation. You get more benefit from the same product.
❌ If your skin is oily and you do not use irritating actives
An oily skin with an intact barrier does not usually need a dense barrier cream. The lighter Dr. Althea 147 version can work better here, or simply your usual moisturiser may be enough.
  • Barrier creams are particularly useful when the skin is irritated by retinoids, acids or environmental stressors such as cold weather.
  • Using a barrier cream over active treatments can improve tolerance by reducing transepidermal water loss.
  • Very oily skins with an intact barrier may prefer lighter textures such as Dr. Althea 147 rather than dense occlusive creams.

345 Relief Cream vs 147 Daily Barrier Cream: which for each moment

Dr. Althea has two key options if you are looking for a good Korean moisturiser with a focus on the skin barrier: 345 (rich, intensive, rescue) and 147 (lightweight, daily, maintenance). They do not compete — they complement each other.


If you can only buy one, I would choose Dr. Althea 345 — it is the one that makes the biggest difference on compromised or reactive skin barriers. If you want a complete routine, use Dr. Althea 147 in the morning and Dr. Althea 345 at night. It is an effective combination for many of my patients.

  • Dr. Althea 345 Relief Cream has a richer texture aimed at intensive support for compromised skin barriers.
  • Dr. Althea 147 Daily Barrier Cream offers a lighter texture better suited to daytime use or combination to oily skins.
  • Many users alternate both creams, using the lighter formula in the morning and the richer one at night for maintenance and rescue.

When and how to apply a barrier cream

Always
As the LAST step in your skincare routine, before sunscreen in the morning. Cleanser → toner → serum → treatment → barrier cream. A barrier cream helps seal in the previous steps and reduce moisture loss.
Post-retinol
Sandwich method: thin layer of 147 → retinol → layer of 345. The first barrier layer buffers the retinol; the second layer helps comfort the skin and reduce dryness. Useful if retinol usually leaves your skin tight, flaky or irritated.
Rescue
If your skin is in crisis — redness, flaking, stinging or burning: stop all active ingredients. Use only gentle cleansing + 345 Relief Cream + sunscreen. Nothing else. Keep it simple for 3–5 days, or until the skin feels comfortable again.
Daily
147 in the morning under sunscreen and make-up. Use a pea-sized amount for the whole face. It absorbs in around 1 minute and gives lightweight, invisible barrier support throughout the day.

Quick view: Dr. Althea 345 vs 147

Active ingredientFunction in the barrierWhat you notice
CeramidesRebuild the lipid structure (the "bricks" of the barrier)Skin retains hydration and stops feeling tight
Centella asiatica (Cica)Soothes inflammation and stimulates tissue repairLess redness, less itching, less stinging
Panthenol (provitamin B5)Hydrates and speeds up cell regenerationSofter, more comfortable skin from the first application
345 mg total complexQuantified concentration of repairing active ingredientsVisible results in 2–3 days on a compromised barrier

In the pharmacy this is the question I get asked most; here are the key points summarised at a glance.

Frequently asked questions

Does Dr. Althea 345 Relief Cream clog pores?

No. Despite being a rich cream, it is not comedogenic. The formula has been tested not to clog pores. It is used on all skin types, including oily and acne-prone skin after treatment. The key is how much you apply: for oily skin, a thin layer is enough.

What does the 345 in Dr. Althea 345 Relief Cream mean?

It refers to 345 mg of cica-ceramide complex per application. It is a way of quantifying the real concentration of repairing active ingredients — it is not an arbitrary name or a marketing code. The 147 has 147 mg of the same complex in a lighter texture.

Should I choose Dr. Althea 345 Relief Cream or 147 Relief Cream?

The 345 is for night-time, post-treatment and rescue care — dense texture, intensive repair. The 147 is for daily use morning and night — light texture, maintenance protection. If you are unsure: use 345 at night, 147 in the morning. If you can only buy one, choose the 345 for its versatility.

Can I use Dr. Althea 345 Relief Cream with retinol?

Yes, and this is one of its star uses. The "sandwich method" (barrier cream → retinol → barrier cream) reduces retinol irritation without blocking its effect. Ceramides and centella asiatica calm inflammation while sealing the active ingredients into the skin.

Does a barrier cream replace my moisturiser?

It can work as moisturiser plus barrier in a single step (for dry skin), or as an occlusive layer over your usual moisturiser (for combination skin that needs less density). The 345 is enough on its own for dry skin. The 147 is enough on its own for combination skin.

Is Dr. Althea 345 Relief Cream suitable for acne-prone skin?

Yes, especially after anti-acne treatments that damage the skin barrier (retinoids, benzoyl peroxide, acids). A compromised skin barrier worsens acne because irritated skin produces more reactive sebum. Repairing the skin barrier is part of acne treatment, not an optional extra.

Can I use Dr. Althea 345 Relief Cream around the eyes?

On the periocular area it works well as a protective, soothing barrier cream. It does not contain specific active ingredients for dark circles or fine lines — for that, apply an eye serum (such as Ondo Beauty Ssu-Dam) underneath and seal with the 345 on top.

How long does Dr. Althea 345 Relief Cream take to improve a very damaged skin barrier?

In my experience dispensing this cream, most patients with a compromised skin barrier notice relief from itching and tightness within the first 24–48 hours. Visible recovery of the barrier — less flaking and redness — usually occurs between day 3 and day 7 with consistent night-time use.

On skin after intensive procedures such as chemical peels or laser, you may need a full week of exclusive use of the 345 before reintroducing any active ingredients. The key is not to stop applying it even if the skin improves quickly.

Scientific references

  • [fuente] [acceder] — https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849435/
  • [fuente] [acceder] — PMID: 24278045
  • Elias, P.M., & Feingold, K.R. (2001). Skin barrier function. Dermatologic Therapy, 14(2), 91–96. [acceder] — PMID: 12553649
  • Berardesca, E., et al. (2001). Effects of topical ceramides on skin barrier function in humans. Journal of Dermatological Treatment, 12(2), 87–91. [acceder] — PMID: 12171676
  • Bylka, W., et al. (2014). Centella asiatica in cosmetology. Postepy Dermatologii i Alergologii, 31(1), 1–7. [acceder] — PMID: 24683386
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