Topical or oral tranexamic acid?

Oral (250-500 mg/day) is more potent and prescribed by dermatologists in severe melasma. Topical (2-5% serum) is OTC, no systemic effects, sufficient for most cases. In very resistant melasma both can be combined.

How long does it take to lighten melasma?

Visible improvement: 8-12 weeks. Maximum result: 4-6 months with consistent use and strict SPF. Melasma requires patience and indefinite consistency — recurs without sustained sun protection.

Is it safe during pregnancy?

Cosmetic topical use at 2-3% is generally considered safe, check with your gynaecologist. Oral use contraindicated. For pregnancy chloasma, priority is strict SPF and treatment after delivery.

Does it cause side effects?

Topical at 2-5% has very safe profile, possible mild irritation at start. Oral has cardiovascular contraindications (thrombotic risk), requires strict medical supervision.

Which actives combine with it?

Synergistic with vitamin C, niacinamide, alpha arbutin and kojic acid. Compatible with retinol on alternating nights. No documented conflicts.

Absolutely. Melasma has photosensitive component — any exposure without SPF 50+ reverses weeks of treatment. Rule number one of any brightening treatment.

Tranexamic Acid | Anti-hormonal pigmentation serums

Tranexamic Acid

Pharmacy serums and treatments with tranexamic acid. A synthetic derivative of lysine with specific brightening action on hormonal spots and melasma. It blocks the interaction between melanocytes and keratinocytes and can reduce the overproduction of melanin. It is the most prescribed active in dermatology for resistant melasma. Concentrations from 2% to 5% in OTC skincare.